Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia.

Alessandra RovidaCristina MaccalliLydia ScarfòPaolo DellabonaKostas StamatopoulosPaolo Ghia

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our data highlight the immunogenicity of stereotyped VH CDR3 sequences and support the feasibility and efficacy of their use for novel cancer vaccine in CLL. Such approach has the advantage to generate "off-the-shelf" therapeutic vaccines for relevant groups of patients belonging to stereotyped subsets.See related commentary by Seiffert, p. 659.

Keyphrases

chronic lymphocytic leukemia
end stage renal disease
ejection fraction
newly diagnosed
papillary thyroid
peritoneal dialysis
prognostic factors
electronic health record
squamous cell carcinoma
young adults
machine learning
patient reported
deep learning