Live cell imaging of macrophage/bacterium interaction demonstrates cell lysis induced by Corynebacterium diphtheriae and Corynebacterium ulcerans.
Dulanthi WeerasekeraJonas HahnMartin HerrmannAndreas BurkovskiPublished in: BMC research notes (2019)
The time lapse fluorescence microscopy data revealed new insights in the interaction of corynebacteria with human macrophage-like THP-1 cells. In contrast to uninfected cells and infections with non-pathogenic C. glutamicum used as a control, pathogenic C. diphtheriae and C. ulcerans showed highly detrimental effects towards human cells and induction of cell death of macrophages.
Keyphrases
- cell cycle arrest
- cell death
- induced apoptosis
- high resolution
- single cell
- endothelial cells
- single molecule
- adipose tissue
- magnetic resonance
- endoplasmic reticulum stress
- signaling pathway
- stem cells
- computed tomography
- pi k akt
- machine learning
- artificial intelligence
- mesenchymal stem cells
- high speed
- induced pluripotent stem cells
- antiretroviral therapy
- energy transfer
- contrast enhanced