Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis.
Albert AboseifNisa VorasootMarcus Vinicius PintoYong GuoShemonti HasanAnastasia ZekeridouJohn J ChenDivyanshu DubeyPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
We report KLHL11-IgG rhombencephalitis associated with poorly differentiated esophageal cancer as a novel nirAE. Tumor staining revealed KLHL11 immunoreactivity, supporting a cancer-antigen-driven ICI-associated paraneoplastic syndrome. Recognition of novel nirAEs can expedite treatment and potentially prevent progressive neurologic disability.