Stem cell transplantation as a progressing treatment for retinitis pigmentosa.
Sedighe Hosseini ShabananHoma SeyedmirzaeiAlona BarneaSara HanaeiNima RezaeiPublished in: Cell and tissue research (2022)
Retinal degenerative diseases such as retinitis pigmentosa (RP) are of the major causes of vision loss in developed countries. Despite the unclear pathophysiology, treatment methods have been investigated vastly in the past decades. This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, neural stem cells, retinal progenitor cells, and olfactory ensheathing cells are discussed separately in addition to a brief description of two approaches for treatment of early-stage RP, including gene therapy and nutritional therapy.
Keyphrases
- stem cells
- stem cell transplantation
- early stage
- mesenchymal stem cells
- optical coherence tomography
- embryonic stem cells
- low dose
- induced pluripotent stem cells
- combination therapy
- mass spectrometry
- lymph node
- bone marrow
- drinking water
- cell proliferation
- signaling pathway
- single molecule
- umbilical cord
- neoadjuvant chemotherapy
- optic nerve