Outpatient diuretic intensification as endpoint in heart failure with preserved ejection fraction trials: an analysis from TOPCAT.
Joao Pedro FerreiraJiankang LiuBrian L ClaggettOrly VardenyBertram PittMarc A PfefferScott D SolomonFaiez ZannadPublished in: European journal of heart failure (2021)
In HFpEF, ODI was frequent and independently associated with subsequent cardiovascular events. Spironolactone significantly reduced an extended composite outcome incorporating ODI.