Clonal hematopoiesis with DNMT3A mutation is associated with lower white matter hyperintensity volume.

Woo-Jin LeeKeun-Hwa JungHan SongHeesun LeeHyo Eun ParkYoungil KohSu-Yeon ChoiKyung-Il Park

Published in: CNS neuroscience & therapeutics (2023)

Clonal hematopoiesis with DNMT3A mutation is quantitatively associated with a lower volume of cerebral WMH, especially in the periventricular region. CHIP with DNMT3A mutation might have a protective role in the endothelial pathomechanism of WMH.

Keyphrases

dna methylation
white matter
endothelial cells
gene expression
high throughput
multiple sclerosis
single cell
hematopoietic stem cell