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Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases.

William T Festuccia
Published in: Molecular nutrition & food research (2020)
In adipocytes, optimal levels of mTORC1 activity are required for its pro-lipogenic actions, while in macrophages, mTORC1 regulates features of both M1 and M2 polarization. mTORC2, on the other hand, promotes glucose uptake and de novo lipogenesis in adipocytes and counteracts macrophage inflammatory response.
Keyphrases
  • adipose tissue
  • inflammatory response
  • insulin resistance
  • high fat diet induced
  • lps induced
  • metabolic syndrome
  • immune response
  • skeletal muscle
  • glycemic control