Muscle involvement in SARS-CoV-2 infection.

Lea PitscheiderMario KarolyiFrancesco R BurkertRaimund HelbokJulia V WanschitzCorinne HorlingsErich PawelkaSara OmidMarianna TraugottTamara SeitzAlexander ZoufalyElisabeth Lindeck-PozzaEwald WöllRonny BeerStefanie SeiwaldRosa Bellmann-WeilerHarald Hegen Wolfgang N Löscher

Published in: European journal of neurology (2020)

HyperCKemia occurs in a similar frequency in COVID-19 and influenza infection. CK levels were lower in COVID-19 than in influenza in mild and severe disease. CK levels strongly correlate with disease severity and markers of inflammation. To date, it remains unclear whether hyperCKemia is due to a virus-triggered inflammatory response or direct muscle toxicity.

Keyphrases

coronavirus disease
sars cov
inflammatory response
oxidative stress
respiratory syndrome coronavirus
skeletal muscle
protein kinase
early onset
immune response