Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis.
Vicente Peris SempereSergio Muñiz-CastrilloAditya AmbatiSophie N M BinksAnne-Laurie PintoVéronique RogemondSean J PittockDivyanshu DubeyMichael D GeschwindJeffrey Marc GelfandSonam DilwaliSoon-Tae LeeJulian KnightKatherine S ElliottSarosh R IraniJérôme HonnoratEmmanuel Jean-Marie MignotPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
In addition to the established primary DRB1*07:01 association in anti-LGI1 encephalitis, we observe a secondary effect of DRB1*04:02 with lower age at onset. Our study provides evidence for secondary effects within HLA locus that correlate with clinical phenotypes in anti-LGI1 encephalitis.
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