Novel biomarkers for acute respiratory distress syndrome: genetics, epigenetics and transcriptomics.
Fei ZhengYiHang PanYang YangCongli ZengXiangming FangQiang ShuQixing ChenPublished in: Biomarkers in medicine (2022)
Acute respiratory distress syndrome (ARDS) can be induced by multiple clinical factors, including sepsis, acute pancreatitis, trauma, intestinal ischemia/reperfusion and burns. However, these factors alone may poorly explain the risk and outcomes of ARDS. Emerging evidence suggests that genomic-based or transcriptomic-based biomarkers may hold the promise to establish predictive or prognostic stratification methods for ARDS, and also to help in the development of novel therapeutic targets for ARDS. Notably, genetic/epigenetic variations correlated with susceptibility and prognosis of ARDS and circulating microRNAs have emerged as potential biomarkers for diagnosis or prognosis of ARDS. Although limited by sample size, ethnicity and phenotypic heterogeneity, ongoing genetic/transcriptomic research contributes to the characterization of novel biomarkers and ultimately helps to develop innovative therapeutics for ARDS patients.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- single cell
- end stage renal disease
- rna seq
- dna methylation
- genome wide
- chronic kidney disease
- copy number
- gene expression
- newly diagnosed
- ejection fraction
- intensive care unit
- acute kidney injury
- type diabetes
- peritoneal dialysis
- machine learning
- skeletal muscle
- glycemic control