Zn(OAc)2-Catalyzed C3-Carbonylacetylation of Indoles with α-Diazoketones Involving Wolff Rearrangement.

Xinwei HuFengjuan ChenYuanfu Deng Huan-Feng Jiang Wei Zeng

Published in: Organic letters (2018)

Zn(OAc)2-catalyzed highly regioselective carbonylacetylation of indoles and pyrroles with α-diazoketones has been developed. This transformation involves a combination of Wolff rearrangement/cross-coupling relay and provides an efficient approach to versatile 3-carbonylacetylindoles and 2-carbonylacetylpyrroles with a broad range of functional group tolerance.

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