Epithelial Mesenchymal and Endothelial Mesenchymal Transitions in Hepatocellular Carcinoma: A Review.

Simona GurzuLaszlo KoboriDecebal FodorIoan Jung

Published in: BioMed research international (2019)

The metastatic pathway of HCC seems to be related to the Wnt- or, rather, TGFβ1-mediated inflammation-angiogenesis-EMT-CSCs crosstalk link. Molecular therapy should target this molecular axis controlling the HCC microenvironment.

Keyphrases

stem cells
bone marrow
endothelial cells
oxidative stress
small cell lung cancer
squamous cell carcinoma
epithelial mesenchymal transition
cell proliferation
vascular endothelial growth factor
cell therapy
mesenchymal stem cells