Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.

Kosuke OgawaQiushi LinLe LiXuewei BaiXuesong ChenHua ChenRui KongYongwei WangHong ZhuFuliang HeQinggang XuLianxin LiuMin LiSonghua ZhangKatsuya NagaokaRolf CarlsonHoward SafranKevin CharpentierBei SunJack R WandsXiaoqun Dong

Published in: Journal of hematology & oncology (2019)

Targeting the ASPH-SRC axis, which is essential for propagating multi-step PDAC metastasis, may specifically/substantially retard development/progression and thus improve prognosis of PDAC.

Keyphrases

signaling pathway
tyrosine kinase
pi k akt
epithelial mesenchymal transition
cancer therapy
induced apoptosis
cell proliferation