Microstructural alterations in the locus coeruleus-entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia.

Giulia QuattriniLorenzo PiniIlaria Boscolo GalazzoIleana O JelescuJorge JovicichRosa ManentiGiovanni B FrisoniMoira MarizzoniFrancesca B PizziniMichela Pievani

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

Microstructural integrity of LC-TEC pathway is understudied in AD and bvFTD.LC-TEC microstructural alterations are present in both AD and bvFTD.Greater LC-TEC microstructural alterations in bvFTD than AD.LC-TEC microstructural alterations in bvFTD are associated to EC neurodegeneration.

Keyphrases

white matter
simultaneous determination
mass spectrometry
multiple sclerosis
solid phase extraction
high resolution
functional connectivity
tandem mass spectrometry