Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice.

C Alicia TraughberKara TiminskiAshutosh PrinceNilam BhandariKalash NeupaneMariam R KhanEsther OpokuEmmanuel OpokuGregory BrubakerJunchul ShinJunyoung HongBabunageswararao Kanuri Elif Gulin Ertugral-Samgar Prabhakara R Nagareddy Chandrasekhar R Kothapalli Olga A Cherepanova Jonathan D Smith Kailash Gulshan

Published in: Journal of the American Heart Association (2024)

Taken together, our data show that disulfiram can simultaneously modulate several atheroprotective pathways in a GsdmD-dependent as well as GsdmD-independent manner.

Keyphrases

cell death
high fat diet induced
electronic health record
endoplasmic reticulum stress
cardiovascular disease
signaling pathway
oxidative stress
big data
type diabetes
machine learning
insulin resistance
metabolic syndrome
adipose tissue
artificial intelligence