Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome.
Ulrich StiffelFrederick VogelGiorgio CarattiMartin ReinckeJan P TuckermannPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Here, we show for the first time a relevant association of the local renin-angiotensin-aldosterone-system and systemic blood pressure levels in patients with Cushing syndrome. Patients from the cluster 3 high expressed group still had increased blood pressure levels after 6 months in remission, highlighting the importance of local tissue effects on long-term systemic effects observed in Cushing syndrome.
Keyphrases
- blood pressure
- gene expression
- adipose tissue
- hypertensive patients
- heart rate
- end stage renal disease
- case report
- ejection fraction
- chronic kidney disease
- angiotensin ii
- genome wide
- insulin resistance
- dna methylation
- high fat diet
- metabolic syndrome
- rheumatoid arthritis
- systemic lupus erythematosus
- disease activity
- patient reported outcomes
- drug induced