RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses.

Zhao-Shan LiuZi-Yu ZhangHong CaiMing ZhaoJie MaoJiang DaiTian XiaXue-Min ZhangTao Li

Published in: Cell & bioscience (2018)

Our study reveals that monoubiquitination is an important regulation for cGAS activation and uncovers a critical role of RINCK in the cGAS-mediated innate immunity.

Keyphrases

immune response
toll like receptor
inflammatory response