Gut microbiota modulates osteoclast glutathione synthesis and mitochondrial biogenesis in mice subjected to ovariectomy.
Yin YuanJing YangAoxiang ZhugeLan-Juan LiShuo NiPublished in: Cell proliferation (2022)
Our results reveal that GSH plays a vital role in OVX-induced bone loss, and probiotics that affect GSH metabolism are potential therapeutic targets for overcoming osteoporosis.
Keyphrases
- bone loss
- fluorescent probe
- oxidative stress
- high glucose
- diabetic rats
- postmenopausal women
- bone mineral density
- high fat diet induced
- genome wide
- single cell
- drug induced
- endothelial cells
- metabolic syndrome
- risk assessment
- type diabetes
- gene expression
- adipose tissue
- skeletal muscle
- insulin resistance
- stress induced