Nail abnormalities identified in an ageing study of 30 inbred mouse strains.
Sarah C LinnAllison M MustonenKathleen A SilvaVictoria E KennedyBeth A SundbergLesley S BechtoldSarah AlghamdiRobert HoehndorfPaul N SchofieldJohn P SundbergPublished in: Experimental dermatology (2018)
In a large-scale ageing study, 30 inbred mouse strains were systematically screened for histologic evidence of lesions in all organ systems. Ten strains were diagnosed with similar nail abnormalities. The highest frequency was noted in NON/ShiLtJ mice. Lesions identified fell into two main categories: acute to chronic penetration of the third phalangeal bone through the hyponychium with associated inflammation and bone remodelling or metaplasia of the nail matrix and nail bed associated with severe orthokeratotic hyperkeratosis replacing the nail plate. Penetration of the distal phalanx through the hyponychium appeared to be the initiating feature resulting in nail abnormalities. The accompanying acute to subacute inflammatory response was associated with osteolysis of the distal phalanx. Evaluation of young NON/ShiLtJ mice revealed that these lesions were not often found, or affected only one digit. The only other nail unit abnormality identified was sporadic subungual epidermoid inclusion cysts which closely resembled similar lesions in human patients. These abnormalities, being age-related developments, may have contributed to weight loss due to impacts upon feeding and should be a consideration for future research due to the potential to interact with other experimental factors in ageing studies using the affected strains of mice.
Keyphrases
- escherichia coli
- inflammatory response
- weight loss
- liver failure
- high fat diet induced
- drug induced
- end stage renal disease
- newly diagnosed
- ejection fraction
- minimally invasive
- respiratory failure
- type diabetes
- metabolic syndrome
- prognostic factors
- intensive care unit
- deep learning
- hepatitis b virus
- body mass index
- adipose tissue
- skeletal muscle
- wild type
- single cell
- lipopolysaccharide induced
- bone regeneration
- mechanical ventilation
- roux en y gastric bypass
- body composition
- amyotrophic lateral sclerosis