Acid Suppression Medications During Hospitalization as a Risk Factor for Recurrence of Clostridioides difficile Infection: Systematic Review and Meta-analysis.

Palna MehtaRonald G NahassLuigi Brunetti

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

ASM use during hospitalization was associated with a 64% increase in recurrent CDI. The association was greater with PPI use. Due to significant heterogeneity in the analyses, additional studies are essential to further elucidate iatrogenic effects of ASM. Unnecessary PPI use should be discontinued.

Keyphrases

clostridium difficile
protein protein
single cell
small molecule
case control
free survival