Airway IL-1β is related to disease severity and mucociliary function in bronchiectasis.

Lidia PereaMathieu BottierErin CantHollian RichardsonAlison J DickerMorven ShuttleworthYan Hui GiamHani Abo-LeyahSimon FinchJeffrey T-J HuangMichal ShteinbergPieter C GoeminneEva PolverinoJosje AltenburgFrancesco BlasiTobias Welte Stefano AlibertiOriol SibilaJames D ChalmersAmelia Shoemark

Published in: The European respiratory journal (2024)

A subset of stable bronchiectasis patients show increased airway IL-1β, suggesting pulmonary inflammasome activation is linked with more severe disease, airway infection, mucus dehydration and epithelial dysfunction.

Keyphrases

cystic fibrosis
end stage renal disease
ejection fraction
chronic kidney disease
prognostic factors
early onset
patient reported outcomes
drug induced