Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns.

John LondoñoAna Maria SantosPaola PeñaEnrique CalvoLuis R EspinosaJohn D ReveilleGilberto Vargas-AlarconCarlos A JaramilloRafael Valle-OñateMabel AvilaConsuelo RomeroJuan F Medina

Published in: BMJ open (2015)

Our data suggest that the presence of HLA-B15 favours the development of isolated/combined peripheral rather than isolated axSpA, while HLA-B27 promotes an isolated/combined axial disease and excludes a peripheral pattern. HLA-B15 should be considered in addition to HLA-B27 when diagnosing patients with SpA according to ASAS criteria.

Keyphrases

chemotherapy induced
electronic health record
ankylosing spondylitis
disease activity
machine learning
big data
rheumatoid arthritis
systemic lupus erythematosus