Higher fracture prevalence and smaller bone size in patients with hEDS/HSD-a prospective cohort study.
Thiberiu BanicaM CoussensC VerrokenP CaldersI De WandeleF MalfaitH-G ZmierczakS GoemaereB LapauwL RombautPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2019)
hEDS/HSD patients have a cortical bone size deficit compared with controls, possibly contributing to their increased fracture risk. They presented with decreased muscle CSA but normal bone/muscle area ratio, suggesting that this bone size deficit is likely secondary to decreased mechanical loading. Further, there were no arguments for accelerated bone loss in hEDS/HSD subjects.