Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6.
Dimitrius Santiago Passos Simões Fróes GuimarãesNinon M F BarriosAndré Gustavo de OliveiraDavid Rizo-RocaMaxence JolletJonathon A B SmithThiago R AraujoMarcos Vinicius da CruzEmilio MarconatoSandro Massao HirabaraAndré Schwambach VieiraAnna KrookJuleen R ZierathLeonardo Reis SilveiraPublished in: Journal of cachexia, sarcopenia and muscle (2024)
Our findings reveal a novel role for Nr2f6 as a molecular transducer that plays a crucial role in maintaining the balance between skeletal muscle contractile function and oxidative capacity. These results have significant implications for the development of potential therapeutic strategies for metabolic diseases and myopathies.