Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice.

Sher Bahadur PoudelRyan R RuffGozde YildirimRichard A MillerDavid E HarrisonRandy StrongThorsten KirschShoshana Yakar

Published in: Arthritis research & therapy (2024)

Our study provides comprehensive insights into the prevalence and progression of primary OA in aged UM-HET3 mice, highlighting the sex-specific effects of MB and MitoQ treatments. The correlations between AC scores and various pathological factors underscore the multifaceted nature of OA and its association with inflammation and subchondral bone changes.

Keyphrases

knee osteoarthritis
high fat diet induced
oxidative stress
risk factors
rheumatoid arthritis
bone mineral density
type diabetes
insulin resistance
wild type
postmenopausal women
skeletal muscle