New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750.
Kuo YongSidra KaleemBin WuZhizhen ZhangPublished in: Marine drugs (2021)
Seven novel compounds, namely peniresorcinosides A-E (1-5), penidifarnesylin A (6), and penipyridinone A (7), together with the 11 known ones 8-17, were isolated from a culture of the marine-associated fungus Penicillium sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher's method, 13C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (1) and B (2) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC50 values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively.
Keyphrases
- high resolution
- magnetic resonance
- induced apoptosis
- cell cycle arrest
- solid state
- mass spectrometry
- density functional theory
- molecular dynamics
- molecular dynamics simulations
- molecular docking
- signaling pathway
- endoplasmic reticulum stress
- electronic health record
- machine learning
- magnetic resonance imaging
- monte carlo
- computed tomography
- electron microscopy
- pi k akt