Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.

Soledad A CamolottoVeronika K BelovaLuke Torre-HealyJeffery M VahrenkampKristofer C BerrettHannah ConwayJill SheaChris StubbenRichard MoffittJason GertzEric L Snyder

Published in: Gut (2020)

Our data show that HNF4α regulates the growth and molecular subtype of PDAC by multiple mechanisms, including activation of the classical gene expression programme and repression of SIX4 and SIX1, which may represent novel dependencies of the basal-like subtype.

Keyphrases

gene expression
dna methylation
nuclear factor
electronic health record
big data
clinical trial
immune response
data analysis