White matter changes in the perforant path area in patients with amyotrophic lateral sclerosis.

Jeroen MollinkM HiemstraK L MillerI N HuszarM JenkinsonJ RaaphorstM WiesmannO AnsorgeM Pallebage-GamarallageA M van Cappellen van Walsum

Published in: Neuropathology and applied neurobiology (2019)

We conclude that degeneration of the perforant path occurs in ALS patients and that this may occur before, or independent of, pTDP-43 aggregation in the dentate gyrus of the hippocampus. Future research should focus on correlating the degree of cognitive decline to the amount of white matter atrophy in the perforant path.

Keyphrases

white matter
amyotrophic lateral sclerosis
cognitive decline
end stage renal disease
mild cognitive impairment
multiple sclerosis
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported outcomes
cerebral ischemia