Network Pharmacology and Molecular Docking Study of Zhishi-Baizhu Herb Pair in the Treatment of Gastric Cancer.

Ying QuXiangyang YangJingxiang LiShuxin ZhangShiying LiMengyuan WangLu ZhouZhiying WangZi LinYuzhang YinJinlong LiuNan WangYang Yang

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

The possible mechanisms of the components of the Zhishi-Baizhu herb pair in treating gastric cancer might be related to luteolin and naringenin, which intervened with the targets AKT1, MMP9, IL-6, CCND1, BCL2, MTOR, and MDM2, and are linked with the PI3K-Akt and IL-17 signaling pathways. This knowledge will lay a solid foundation for further experimental and clinical studies.

Keyphrases

molecular docking
signaling pathway
cell proliferation
molecular dynamics simulations
healthcare
pi k akt
combination therapy
replacement therapy