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TF-FVIIa PAR2-β-Arrestin in Mouse Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection.

Meike KespohlCarl Christoph GoetzkeNadine AlthofClara BredowNicolas KelmSandra PinkertThomas BukurValesca BukurKristin GrunzDilraj KaurArnd HeuserMichael MullederMartina SauterKarin KlingelHartmut WeilerNikolaus BerndtMatthias M GaidaWolfram RufAntje Beling
Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)
These data provide insights into a TF-FVIIa signaling axis through PAR2-β-arrestin coupling that is a regulator of inflammation-triggered tissue repair and hemodynamic compromise in coxsackievirus B3 infection and can potentially be targeted with selective coagulation inhibitors.
Keyphrases
  • oxidative stress
  • transcription factor
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  • big data
  • machine learning
  • drug delivery
  • artificial intelligence
  • deep learning