Effects of sevoflurane and clonidine on acid base status and long-term emotional and cognitive outcomes in spontaneously breathing rat pups.

Nicole AlmenraderPaola ColucciValentina De CastroDaniela ValeriMaura PalmeryViviana TrezzaPatrizia Campolongo

Published in: PloS one (2017)

Sixty minutes of sevoflurane anaesthesia in newborn rats, either alone or combined with clonidine, caused severe hypercapnic acidosis in spontaneously breathing rat pups, but was devoid of long-term behavioural dysfunctions in the present setting.

Keyphrases

oxidative stress
early onset
type diabetes
intensive care unit
respiratory failure
metabolic syndrome
drug induced
insulin resistance
extracorporeal membrane oxygenation