Atypical Femoral Fracture in Hypophosphatasia: A Systematic Review.
Nipith CharoenngamJerapas ThongpiyaPitchaporn YingchoncharoenBen PonvilawanMehmet S MarangozJirat ChenbhanichPatompong UngprasertPublished in: International journal of endocrinology (2023)
Based on the limited evidence, AFF occurred in up to 10% of patients with HPP. Based on the 28 case reports, about two-thirds did not receive antiresorptive treatment, suggesting that the HPP itself could potentially be a risk factor for AFF.