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Effect of dapagliflozin in patients with diabetes and heart failure with mildly reduced or preserved ejection fraction according to background glucose-lowering therapy: A pre-specified analysis of the DELIVER trial.

Mats Christian Højbjerg LassenJohn W OstrominskiSilvio E InzucchiBrian L ClaggettIan KulacPardeep JhundRudolf A de BoerAdrian F HernandezMikhail N KosiborodCarolyn S P LamFelipe A MartinezSanjiv J ShahAkshay S DesaiMagnus PeterssonAnna Maria LangkildeKieran F DochertyJohn J V McMurrayScott D SolomonMuthiah Vaduganathan
Published in: European journal of heart failure (2024)
Dapagliflozin safely and consistently improved clinical outcomes among individuals with T2D and HF with LVEF >40% irrespective of the number and class of background GLTs, and the benefits were not influenced by concomitant metformin or insulin use. These data bolster contemporary guidelines supporting first-line SGLT2i among individuals with T2D and HF, irrespective of background GLT.
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