Chronic foetal hypoxaemia does not cause elevation of serum markers of brain injury.
Camilla OmannKendall M LawrenceMallory L HuntJames K MoonJamuna BuchananDaniel J LichtRichard F IttenbachPatrick McGovernJonathan M ChenMarcus DaveyVibeke E HjortdalAlan W FlakeJ William GaynorPublished in: Cardiology in the young (2021)
Chronic foetal hypoxaemia during mid-gestation is not associated with elevated serum levels of acute white matter (Myelin Basic Protein) or astrocyte injury (Glial Fibrillary Acidic Protein), in this model. In conjunction with our previously reported findings, our data support the hypothesis that the brain dysmaturity with impaired myelination found in fetuses with chronic hypoxaemia is caused by disruption of normal developmental pathways rather than by direct cellular injury.
Keyphrases
- brain injury
- white matter
- gestational age
- subarachnoid hemorrhage
- multiple sclerosis
- drug induced
- cerebral ischemia
- liver failure
- protein protein
- electronic health record
- small molecule
- amino acid
- resting state
- neuropathic pain
- respiratory failure
- preterm birth
- extracorporeal membrane oxygenation
- functional connectivity
- artificial intelligence
- acute respiratory distress syndrome