Dermatomyositis presenting with diffuse calcinosis.
Madalyn WalshBrittany BettendorfCarleigh ZahnPublished in: BMJ case reports (2023)
We present the case of a woman in her early 50s who initially presented to an orthopedist for nodules located near the posterior knee. Imaging revealed diffuse subcutaneous calcifications and she was subsequently referred to rheumatology. Additional testing included myositis panel, electromyography (EMG) and muscle biopsy which indicated the presence of an inflammatory myopathy. It was determined that this patient had an uncommon presentation of dermatomyositis in which her primary complaint was calcinosis cutis. While rash and muscle weakness are often the symptoms most commonly associated with dermatomyositis, it is essential to have a wide differential for patients presenting with calcium deposition in soft tissues. This is particularly important in patients with certain antibodies, including the NXP-2 antibody, which can be associated with malignancy and should prompt an appropriate malignancy workup.
Keyphrases
- interstitial lung disease
- case report
- systemic sclerosis
- rheumatoid arthritis
- disease activity
- idiopathic pulmonary fibrosis
- skeletal muscle
- low grade
- high resolution
- total knee arthroplasty
- gene expression
- oxidative stress
- ultrasound guided
- juvenile idiopathic arthritis
- single cell
- knee osteoarthritis
- high density
- myasthenia gravis
- fine needle aspiration
- muscular dystrophy
- photodynamic therapy