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Proteomic analysis of bone marrow-derived mesenchymal stem cell extracellular vesicles from healthy donors: implications for proliferation, angiogenesis, Wnt signaling, and the basement membrane.

Jeffrey D McBrideLuis Rodriguez-MenocalWellington GuzmanAisha KhanCiara MyerXiaochen LiuSanjoy K BhattacharyaEvangelos V Badiavas
Published in: Stem cell research & therapy (2021)
Healthy donors of BM-MSC EVs contain important similarities and differences among protein cargo that may play important roles in their pro-regenerative functions. Further studies are needed to correlate proteomic signatures to functional outcomes in cutaneous repair.
Keyphrases
  • mesenchymal stem cells
  • umbilical cord
  • stem cells
  • cell therapy
  • kidney transplantation
  • bone marrow
  • endothelial cells
  • signaling pathway
  • genome wide
  • vascular endothelial growth factor
  • dna methylation
  • small molecule