New cyclic diarylheptanoids from the false heartwood of Betula pubescens Ehrh.
Anastasiia O PonkratovaDmitry N VedernikovAndrei K WhaleyMaria N KuncovaSergey N SmirnovVladimir SharoykoDaria V SpiridonovaVladimir G LuzhaninPublished in: Natural product research (2021)
Two undescribed ( 1 - 2) and five known cyclic diarylheptanoids ( 3 - 7 ) were isolated from the false heartwood of white birch ( Betula pubescens Ehrh.). All structures were elucidated through extensive 1D and 2D NMR experiments and HR-ESI-MS data, along with comparison of their spectroscopic data with those reported in the literature. The two new cyclic diarylheptanoids are betuladiol ( 1 ) and betulondiol ( 2 ). Extracts from false heartwood were evaluated for their antimicrobial activity against Klebsiella pneumoniae , Escherichia coli , Proteus mirabilis, Staphylococcus aureus and Cutibacterium acnes together with their antifungal activity against Candida albicans and Candida glabrata .
Keyphrases
- candida albicans
- klebsiella pneumoniae
- biofilm formation
- escherichia coli
- staphylococcus aureus
- ms ms
- multidrug resistant
- electronic health record
- high resolution
- big data
- systematic review
- mass spectrometry
- multiple sclerosis
- molecular docking
- pseudomonas aeruginosa
- cystic fibrosis
- data analysis
- machine learning
- solid state
- methicillin resistant staphylococcus aureus
- artificial intelligence