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Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines.

Joseph C AbellChristian Paul BoldLaia VicensTom JentschNoelia VelascoJasper L TylerRobert N StrakerAdam NobleVarinder Kumar Aggarwal
Published in: Organic letters (2023)
The identification of the beneficial pharmacokinetic properties of aza-spirocycles has led to the routine incorporation of these highly rigid and three-dimensional structures in pharmaceuticals. Herein, we report an operationally simple synthesis of spirocyclic dihydropyridines via an electrophile-induced dearomative semi-pinacol rearrangement of 4-(1'-hydroxycyclobutyl)pyridines. The various points for diversification of the spirocyclization precursors, as well as the synthetic utility of the amine and ketone functionalities in the products, provide the potential to rapidly assemble medicinally relevant spirocycles.
Keyphrases
  • high glucose
  • diabetic rats
  • drug induced
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  • climate change
  • mass spectrometry