Overweight/Obesity Increases the Risk of Overt Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt in Cirrhotic Patients.
Lihong GuXiaochun YinYang ChengXixuan WangMing ZhangXiaoping ZouLei WangYuzheng ZhugeFeng ZhangPublished in: Journal of personalized medicine (2023)
The purpose of this study was to investigate the effect of body mass index (BMI) on the prevalence of overt hepatic encephalopathy (OHE) after the transjugular intrahepatic portosystemic shunt (TIPS) procedure in decompensated cirrhotic patients. A retrospective observational cohort study of 145 cirrhotic patients receiving TIPS was carried out in our department from 2017 to 2020. The relationships between BMI and clinical outcomes including OHE, as well as risk factors of developing post-TIPS OHE, were analyzed. BMI was categorized as normal weight (18.5 ≤ BMI < 23.0 kg/m 2 ), underweight (BMI < 18.5 kg/m 2 ), and overweight/obese (BMI ≥ 23.0 kg/m 2 ). Among the 145 patients, 52 (35.9%) were overweight/obese and 50 (34%) had post-TIPS OHE. Overweight/obese patients more frequently had OHE compared with normal weight patients (OR: 2.754, 95% CI: 1.236-6.140; p = 0.013). Overweight/obesity ( p = 0.013) and older age ( p = 0.030) were independent risk factors for post-TIPS OHE according to the logistic regression analysis. Kaplan-Meier curve analysis suggested that overweight/obese patients had the highest cumulative incidence of OHE (log-rank p = 0.0118). In conclusion, overweight/obesity and older age may raise the risk of post-TIPS OHE in cirrhotic patients.
Keyphrases
- weight gain
- body mass index
- weight loss
- obese patients
- end stage renal disease
- physical activity
- ejection fraction
- bariatric surgery
- risk factors
- newly diagnosed
- chronic kidney disease
- metabolic syndrome
- roux en y gastric bypass
- prognostic factors
- gastric bypass
- heart failure
- early onset
- pulmonary artery
- tertiary care
- middle aged
- coronary artery
- skeletal muscle
- body weight
- patient reported
- high fat diet induced