Shared hippocampal abnormalities in sporadic temporal lobe epilepsy patients and their siblings.
Lili LongMarian GalovicYayu ChenTjardo PostmaSjoerd B VosFenglai XiaoWenyue WuYanmin SongSha HuangMatthias J KoeppBo XiaoPublished in: Epilepsia (2020)
Our results demonstrate a shared vulnerability of the hippocampus in both patients with TLE and their unaffected siblings, pointing to a contribution of familial factors to hippocampal atrophy. This neuroimaging trait could represent an endophenotype of TLE, which might precede the onset of epilepsy in some individuals.