Insight into the relationship between resting heart rate and atrial fibrillation: A Mendelian Randomization study.
Marie KlevjerHumaira RasheedPål Richard RomundstadErik MadssenBen Michael BrumptonAnja ByePublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2023)
In contrast with the current observational knowledge of RHR and AF, an inverse causal association between RHR and AF was demonstrated in both linear and non-linear MR for RHR values up to 90 bpm. Further exploring the underlying mechanisms of the genetic instrument for RHR may shed light on whether pleiotropy is biasing this association.
Keyphrases
- heart rate
- atrial fibrillation
- heart rate variability
- blood pressure
- magnetic resonance
- catheter ablation
- oral anticoagulants
- left atrial
- healthcare
- left atrial appendage
- contrast enhanced
- direct oral anticoagulants
- heart failure
- computed tomography
- magnetic resonance imaging
- percutaneous coronary intervention
- dna methylation
- gene expression
- patient reported outcomes
- venous thromboembolism
- acute coronary syndrome