Temporal dynamics of epigenetic aging and frailty from midlife to old age.
Jonathan K L MakIda K KarlssonBowen TangYunzhang WangNancy L PedersenSara HäggJuulia JylhäväChandra A ReynoldsPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
Our results highlight a temporal order between epigenetic aging and frailty such that changes in DunedinPACE precede changes in the FI. This potentially suggests that the pace of aging clock can be used as an early marker of the overall physiological decline at system level.