Differences in Prostate Cancer Transcriptomes by Age at Diagnosis: Are Primary Tumors from Older Men Inherently Different?
Charlie D ZhouAndreas PetterssonAnna PlymSvitlana TyekuchevaKathryn L PenneyHoward D SessoPhilip W KantoffLorelei A MucciKonrad H StopsackPublished in: Cancer prevention research (Philadelphia, Pa.) (2022)
Older age at diagnosis is consistently associated with worse clinical outcomes in prostate cancer. This study with independent discovery and validation sets and long-term follow-up suggests that prevention of lethal prostate cancer should focus on implementing appropriate screening, staging, and treatment among older men without expecting fundamentally different tumor biology.