Novel mechanism of cisplatin resistance in head and neck squamous cell carcinoma involving extracellular vesicles and a copper transporter system.
Tatsuo OgawaKisho OnoShoji RyumonHotaka KawaiTomoya NakamuraKoki UmemoriKunihiro YoshidaHideka KanemotoKyoichi ObataNorie YoshiokaTatsuo OkuiKuniaki OkamotoHitoshi NagatsukaSoichiro IbaragiPublished in: Head & neck (2024)
EVs were involved in the ATP7B-mediated mechanism underlying CDDP resistance. Further clarification of the EV-induced CDDP-resistance mechanism may lead to novel therapeutic strategies for HNSCC.