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First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas.

Sarina A Piha-PaulRavit GevaTira J TanDarren Wt LimCinta HierroToshikiko DoiOsama RahmaAlexander LesokhinJason John LukeJavier OteroLisa NardiAngad SinghAlexandros XyrafasXinhui ChenJennifer MatarazaPhilippe L Bedard
Published in: Journal for immunotherapy of cancer (2022)
NCT02740270.
Keyphrases
  • open label
  • endothelial cells
  • clinical trial
  • phase ii
  • study protocol
  • phase iii
  • induced pluripotent stem cells
  • squamous cell carcinoma