Synthesis of Diaryl Ethers via Hypervalent Iodine-Mediated C-H Functionalization.
Chenghu HuQi JiaWenjing BaoGuangxing GuYa LiYanchuan ZhaoPublished in: Organic letters (2024)
A hypervalent iodine-reagent-based C-H functionalization strategy was utilized to synthesize diaryl ethers. This method directly transforms various arenes into their corresponding diaryliodonium salts, followed by a C-O coupling reaction to produce structurally diverse diaryl ethers. The efficacy of this approach in the late-stage structural modifications of complex molecules was demonstrated.