NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells.
Yun XuMasoud NasriBenjamin DannenmannPerihan MirAzadeh ZahabiKarl WelteTatsuya MorishimaJulia SkokowaPublished in: Stem cell research & therapy (2021)
Our data demonstrate the essential role of the NAMPT/SIRT2/p53/p21 signaling axis in the maintenance and hematopoietic differentiation of iPS cells.