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K+ promotes the favorable effect of polyamine on gene expression better than Na.

Takashi NishioKaito SuginoYuko YoshikawaMichiaki MatsumotoYohei OeKoichiro SadakaneKenichi Yoshikawa
Published in: PloS one (2020)
We found that Na+ and K+ exhibit markedly different effects through competitive binding with a cationic polyamine, SPD, to DNA, which causes a large difference in the higher-order structure of genomic DNA. It is concluded that the larger favorable effect of Na+ than K+ on in vitro gene expression observed in this study is well attributable to the significant difference between Na+ and K+ on the competitive binding inducing conformational transition of DNA.
Keyphrases
  • gene expression
  • single molecule
  • circulating tumor
  • cell free
  • dna methylation
  • nucleic acid
  • molecular dynamics
  • molecular dynamics simulations
  • copy number