Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis.
Amandeep Kaur DhillonChristian RuppAnnika BergquistRobert VoitlTrine FolseraasMarius TrøseidØivind MidttunPer M UelandTom H KarlsenMette VesterhusMartin KummenJohannes Roksund HovPublished in: Scandinavian journal of gastroenterology (2021)
Neopterin and KT-ratio were elevated in PSC and associated with liver transplantation-free survival in two independent PSC cohorts, highlighting a possible role of interferon gamma-driven inflammation in the pathogenesis. However, the lack of association with survival in one of the cohorts reduces the potential clinical value of neopterin and KT-ratioas biomarkers and highlights the need to validate new biomarkers in PSC in multiple cohorts.