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γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.

Xiaoli ZhangEridan Rocha-FerreiraTao LiRegina VontellDarakhshan JabinSha HuaKai ZhouArshed NazmiAnna-Maj AlbertssonKristina SobotkaJoakim EkClaire ThorntonHenrik HagbergCarina MallardJianmei W LeavenworthChanglian ZhuXiaoyang Wang
Published in: Journal of neuroinflammation (2017)
Our results suggest that γδT cells but not αβT cells contribute to sepsis-induced white matter injury and subsequent motor function abnormalities in early life. Modulating the activity of γδT cells in the early stages of preterm white matter injury might represent a novel therapeutic strategy for the treatment of perinatal brain injury.
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